Thrombophilia, polymorphisms, and vascular disease
نویسندگان
چکیده
منابع مشابه
Thrombophilia, polymorphisms, and vascular disease.
Thrombophilia traditionally refers to rare inherited defects leading to enhanced coagulation, especially of the venous system. In recent years, a broader search for genetic polymorphisms of prothrombotic genes has been carried out to determine the relative impact on venous and arterial thrombosis. The bulk of evidence is drawn from numerous, often small, heterogeneous, case control association ...
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Venous thrombosis aVects one in 1000 individuals per year 2 causing significant morbidity and mortality. Inherited thrombophilia is a genetically determined tendency to thrombosis. Dominant abnormalities or combinations of mutations of varying penetrance giving rise to less severe defects may be suspected clinically from evidence of early age of onset, frequent recurrence, or family history. Mi...
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PURPOSE The purpose of this research was to assess associations of thrombophilia with central retinal vein occlusion (CRVO), central retinal artery occlusion (CRAO), and amaurosis fugax (AF); to evaluate outcomes of normalizing high homocysteine; and to study CRVO, CRAO, and AF developing in estrogens/estrogen agonists in women subsequently shown to have thrombophilia. METHODS Measures of thr...
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OBJECTIVE To estimate the relationship between the risk of preeclampsia and two thrombophilia gene single-nucleotide polymorphisms (SNPs), the factor V G1691A SNP and the prothrombin G20210A SNP. DATE SOURCES A systematic search of the English-language literature up to November 2012 was performed using Medline and EMBASE. Search terms included "preeclampsia," "thrombophilia," "factor V Leiden...
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The protein C anticoagulant pathway plays a crucial role as a regulator of the blood clotting cascade. Protein C is activated on the vascular endothelial cell membrane by the thrombin-thrombomodulin complex. Once formed, activated protein C (APC) down-regulates thrombin formation by inactivating factors (F)Va and FVIIIa. Endothelial protein C receptor (EPCR) is able to bind protein C and increa...
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ژورنال
عنوان ژورنال: Molecular Pathology
سال: 2000
ISSN: 1366-8714
DOI: 10.1136/mp.53.6.300